2-氨基-5-甲基苯甲酸合成路线 （共 102 条）
反应条件
1: With acetic acid in water T=30°C; 2.5 h; Reflux; 2: With sodium hydroxide in water T=90°C; 1 h;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
参考文献
Mao, Yongjun; Lin, Nan; Tian, Wang; Han, Xiaofeng; Han, Xiaobing; Huang, Ziwei; An, Jing
Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1346 - 1359
反应条件
iodine; isopentyl nitrite in 1,4-dioxane; chloroform-d1 Heating;
参考文献
Perry, Robert J.; Turner, S. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6573 - 6579
反应条件
1: (i) (diazotization), (ii) aq. Na2S2, (iii) aq. Na2S2O4,(iv) (methylation) 2: LiAlH4 / tetrahydrofuran 3: SOCl2 / benzene 4: hexamethylenetetramine, aq. AcOH View Scheme
参考文献
Ruwet,A.; Renson,M.
Bulletin des Societes Chimiques Belges, 1969 , vol. 78, p. 571 - 582
反应条件
sulfuric acid 72 h; Reflux;
参考文献
Lawson, Christopher P. A. T.; Slawin, Alexandra M. Z.; Westwood, Nicholas J.
Chemical Communications, 2011 , vol. 47, # 3 p. 1057 - 1059
反应条件
sulfuric acid in methanol; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5128356 A1, 1992 ;
反应条件
in methanol; hexane; toluene T=20°C; 1 h;
参考文献
Lew, Willard; Baskaran, Subramanian; Oslob, Johan D.; Yoburn, Joshua C.; Zhong, Min
Patent: US2006/35908 A1, 2006 ;
Location in patent: Page/Page column 62 ;
US 20060035908 A1
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; water 2: 2-amino-5-methyl-benzoic acid in diethyl ether 1 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
in diethyl ether 1 h; Inert atmosphere;
参考文献
Levesque, Patrick; Fournier, Pierre-Andre
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7033 - 7036
参考文献
Kulkarni, Shridhar S.; Singh, Satyakam; Shah, Janki R.; Low, Woon-Kai; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 264 - 273
