2-氨基-5-甲基苯甲酸合成路线 （共 102 条）
反应条件
2: concentrated H2SO4
View Scheme
参考文献
Bergmann et al.
Bulletin de la Societe Chimique de France, 1951 , p. 669,680
反应条件
1: 53 percent / CH2Cl2 / 25 °C
2: 92 percent / NH3 / dimethylformamide / 18 h / 25 °C
View Scheme
参考文献
Patil; Jones; Nair; Galivan; Maley; Kisliuk; Gaumont; Duch; Ferone
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 70 percent / tetrahydrofuran / 12 h / 20 °C
2: 87 percent / fuming HNO3 / 1 h / 4 °C
3: 92 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1: 1.) thionyl chloride / 1.) -10 to -15 deg C, 40 min, 2.) -10 deg C - room temperature, 2 h, reflux, 21 h
2: 83 percent / pyridine / 2 h / 25 °C
3: 1.) sodium hydride / 1.) DMF, <20 deg C, 30 min, 2.) 25 deg C, 2 h
4: 95 percent / phenol, HBr / acetic acid / 16.5 h / 25 °C
View Scheme
参考文献
Jones; Betteridge; Newell; Jackman
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1501 - 1507
反应条件
sulfuric acid; nitrobenzene
7 h; RefluxInert atmosphere;
参考文献
Wang, Jingjing; Zuo, Sujing; Chen, Weiqiang; Zhang, Xinrui; Tan, Kaixin; Tian, Yun; Wang, Jianhui
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8217 - 8231
反应条件
in ethanol
3 h; Reflux;
参考文献
Asadi, Mehdi; Masoomi, Shiva; Ebrahimi, Seyed Mostafa; Mahdavi, Mohammad; Saeedi, Mina; Shafiee, Abbas; Foroumadi, Alireza
Monatshefte fur Chemie, 2014 , vol. 145, # 3 p. 497 - 504
反应条件
acetic anhydride in dichloromethane
参考文献
Boehringer Ingelheim KG
Patent: US5116971 A1, 1992 ;
US 5116971 A
参考文献
Mosley, Cara A.; Acker, Timothy M.; Hansen, Kasper B.; Mullasseril, Praseeda; Andersen, Karen T.; Le, Phuong; Vellano, Kimberly M.; Braeuner-Osborne, Hans; Liotta, Dennis C.; Traynelis, Stephen F.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5476 - 5490
反应条件
triphenyl phosphite in pyridine
T=150°C; 0.166667 h; microwave irradiation;
参考文献
Liu, Ji-Feng; Lee, Jaekyoo; Dalton, Audra M.; Bi, Grace; Yu, Libing; Baldino, Carmen M.; McElory, Eric; Brown, Matt
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1241 - 1244
反应条件
1: 62 percent / HCl / 2 h / Heating
2: 82 percent / conc. HCl, CaCO3 / H2O; 1,2-dichloro-ethane / 1 h
3: 74 percent / ethanol / 1 h / Heating
4: 100percent N2H4*H2O / ethanol / 8 h / Heating
5: 69 percent / NaNO2, 5M HCl / 0.25 h
View Scheme
参考文献
Kennewell, Peter D.; Scrowston, Richard M.; Shenouda, Ibrahim G.; Tully, W. Roger; Westwood, Robert
Journal of Chemical Research, Miniprint, 1986 , # 7 p. 2001 - 2025
