4,10-二氮杂-12-冠4-醚合成路线 （共 13 条）
反应条件
ammonia; 4,5-bis(dicyclohexylphosphinomethyl)acridine in toluene T=155°C; P=31278.1 Torr; 15 h; AutoclaveInert atmosphere;
参考文献
US2012/232293 A1, ;
Page/Page column 12; 17 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 72 h; Heating;
参考文献
Cram, Donald J.; Ho, Siew Peng; Knobler, Carolyn B.; Maverick, Emily; Trueblood, Kenneth N.
Journal of the American Chemical Society, 1986 , vol. 108, # 11 p. 2989 - 2998
反应条件
hydrogen bromide; phenol T=80°C; 60 h;
参考文献
Boerjesson, L.; Welch, C. J.
Acta Chemica Scandinavica, 1991 , vol. 45, # 6 p. 621 - 626
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 48 h; Heating;
参考文献
Quici, Silvio; Manfredi, Amedea; Maestri, Mauro; Manet, Ilse; Passaniti, Paolo; Balzani, Vincenzo
European Journal of Organic Chemistry, 2000 , # 11 p. 2041 - 2046
反应条件
1: 75 percent / triethylamine, 4-dimethylaminopyridine (DMAP) / CH2Cl2 / 2 h / Ambient temperature 2: 1.) sodium hydride / 1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h 3: 100 percent / phenol, 33percent HBr in acetic acid / 60 h / 80 °C View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 45, # 6 p. 621 - 626
反应条件
1: 1.) sodium hydride / 1.) DMF, 80 deg C, 2.5 h, 2.) DMF, 80 deg C, 24 h 2: 100 percent / phenol, 33percent HBr in acetic acid / 60 h / 80 °C View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 45, # 6 p. 621 - 626
反应条件
in dichloromethane 18 h; Ambient temperature;
参考文献
Ostaszewski, Ryszard; Jurczak, Janusz
Tetrahedron, 1997 , vol. 53, # 23 p. 7967 - 7974
反应条件
sodium carbonate in acetonitrile 24 h; Heating;
参考文献
Mendez, Luis; Singleton, Raymond; Slawin, Alexandra M. Z.; Stoddart, J. Fraser; Williams, David J.; Williams, M. Kevin
Angewandte Chemie, 1992 , vol. 104, # 4 p. 456 - 459
参考文献
Luk'yanenko N. G.; Reder, A. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 12 p. 1394 - 1395
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 12 p. 1673 - 1675
反应条件
in tetrahydrofuran; ethanol
10 h; Heating;
参考文献
Lukyanenko, Nikolay G.; Reder, Anatoly S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2533 - 2536
