1: With sodium tetrahydroborate; sulfuric acid in tetrahydrofuran; diethyl ether T=0 - 20°C; 20 h; Inert atmosphere; 2: With hydrogenchloride in water T=20°C; 2 h;
5-(ethylthio)methyl-3-hydroxy-2-Me-4-pyridinecarbaldehyde; CHES buffer; potassium chloride; ethylenediaminetetraacetic acid in water T=20°C; Kinetics; Further Variations:Reagents;
参考文献
Liu, Lei; Breslow, Ronald
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 12 p. 3277 - 3287
1: 1.3 g / SOCl2 / 48 h / Ambient temperature 2: dioxane / 18 h / Ambient temperature 3: DIBAH / CH2Cl2; toluene / 2 h / -78 °C 4: NaBH4 / methanol / 0.5 h / 0 °C View Scheme
