10,11-二氢-10-羟基卡马西平合成路线 （共 14 条）
反应条件
palladium 10 on activated carbon; ammonium formate in methanol; dichloromethane; water T=20°C; 1 h; Inert atmosphere;
参考文献
KANDULA, Mahesh
Patent: WO2013/167985 A1, 2013 ;
Location in patent: Paragraph 00102; 00103 ;
参考文献
Portela and Ca., S.A.
Patent: EP1477480 A1, 2004 ;
Location in patent: Page 6, 7 ;
反应条件
sodium tetrahydroborate; water in methanol T=25 - 65°C; 2.75 h;
参考文献
RANBAXY LABORATORIES LIMITED; HIRPARA, Ketan; KHANDURI, Chandra, Has; SHARMA, Mukesh, Kumar
Patent: WO2013/8194 A2, 2013 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
sodium perborate; ethanol; water 0.05 h; Microwave irradiation; Product distribution / selectivity;
参考文献
Panunzio, Mauro; Campana, Eileen; Breviglieri, Gabriele
Patent: US2008/221320 A1, 2008 ;
Location in patent: Page/Page column 2 ;
反应条件
2-hydroxy-1,3-isoindolinedione; oxygen; benzaldehyde; nickel diacetate in acetic acid T=22°C; P=750.06 Torr; 5 h; Product distribution; Further Variations:CatalystsReagentsSolventsreaction time;
参考文献
De Vondervoort, Lizette Schmieder-van; Bouttemy, Sabine; Heu, Ferdinand; Weissenboeck, Kurt; Alsters, Paul L.
European Journal of Organic Chemistry, 2003 , # 3 p. 578 - 586
反应条件
1: potassium permanganate on alumina; sodium carbonate; AcOOH; acetic acid / dichloromethane / 1.67 h / |Reflux 2: ammonium formate; palladium 10 on activated carbon / dichloromethane; methanol; water / 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Tian, Maoqun; Abdelrahman, Aliaa; Weinhausen, Stephanie; Hinz, Sonja; Weyer, Stefanie; Dosa, Stefan; El-Tayeb, Ali; Mueller, Christa E.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1077 - 1088
反应条件
Streptomyces violascens;
参考文献
Kittelman, Matthias; Lattmann, Rene; Ghisalba, Preste
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 9 p. 1589 - 1590
反应条件
peracetic acid; potassium dichromate; hydrogen in 1,2-dichloro-ethane T=20°C; 1 h;
参考文献
Tian, Maoqun; Abdelrahman, Aliaa; Weinhausen, Stephanie; Hinz, Sonja; Weyer, Stefanie; Dosa, Stefan; El-Tayeb, Ali; Mueller, Christa E.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1077 - 1088
反应条件
1: Licarbazepine With pyridine in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2,5-dioxotetrahydrofuran-3,4-diyldiacetate in ethyl acetate T=30 - 35°C; 1 h; Overall yield = 77.08 percent; Overall yield = 0.7 g; Further stages;
参考文献
RANBAXY LABORATORIES LIMITED; HIRPARA, Ketan; KHANDURI, Chandra, Has; SHARMA, Mukesh, Kumar
Patent: WO2013/8194 A2, 2013 ;
Location in patent: Page/Page column 13 ;
反应条件
1: pyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 2: sodium carbonate / 2-methyl tetrahydrofuran / 30 °C / pH 6.8 - 7.3 / Aqueous phosphate buffer; Enzymatic reaction View Scheme
参考文献
INTAS PHARMACEUTICALS LIMITED; DESAI, Sanjay, Jagdish; PANDYA, Ashesh, Kamalnayan; SAWANT, Sachin, Panditrao; MEHARIYA, Krunalkumar, Ramanlal
Patent: WO2011/117885 A1, 2011 ;
