2-甲基-3-氧代己酸乙酯合成路线 （共 19 条）
反应条件
triethylamine; triethyl phosphite in acetonitrile
Heating;
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
1: 11.9 g / P4S10; pyridine / 2 h / Heating
2: 60 percent / Et3N; P(OEt)3 / acetonitrile / Heating
View Scheme
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
1: pyridine / 0.5 h / Heating
2: 30.2 g / P4S10; pyridine / 2 h / Heating
3: 30 percent / Et3N; P(OEt)3 / acetonitrile / Heating
View Scheme
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
1: pyridine / 0.5 h / Heating
2: 11.9 g / P4S10; pyridine / 2 h / Heating
3: 60 percent / Et3N; P(OEt)3 / acetonitrile / Heating
View Scheme
参考文献
Bellec, Christian; Gaurat, Olivier
Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1289 - 1293
反应条件
sodium ethanolate
T=80°C;
参考文献
Glacet
Annales de Chimie (Cachan, France), 1947 , vol. <12>2, p. 329
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946 , vol. 222, p. 501,502,503
反应条件
(i) NaH, (ii) nBuLi, (iii) /BRN= 1209224/; Multistep reaction;
参考文献
Huckin,S.N.; Weiler,L.
Journal of the American Chemical Society, 1974 , vol. 96, p. 1082 - 1087
参考文献
v. Auwers; Dersch
Justus Liebigs Annalen der Chemie, 1928 , vol. 462, p. 117
反应条件
(i) benzene, (ii) (electrolysis); Multistep reaction;
参考文献
Bestmann,H.J. et al.
Chemische Berichte, 1970 , vol. 103, p. 2794 - 2801
反应条件
1: 1.) NaH, LDA; 2.) DBU / 1.) THF, -78 deg C, 1 h; 2.) benzene, 60 deg C, 3 h
2: 61 percent / CH2Cl2 / 4 h / Ambient temperature
3: H2 / Pd/C / methanol / 3 h / 50 °C
4: pyridine; CH2Cl2 / 2 h / Ambient temperature
5: K2CO3 / methanol / 0.5 h / Ambient temperature
6: OsO4, NMO / acetonitrile; H2O / 12 h / Ambient temperature
7: 84 percent / imidazole / dimethylformamide / 4 h / 0 °C
8: 95 percent / pyridine / 1 h / 0 °C
9: 93 percent / NaN3 / dimethylformamide / 4 h / Ambient temperature
10: H2 / Pd-C / methanol
11: 93 percent / DCC, HOBt, Et3N / tetrahydrofuran / 5 h / Ambient temperature
12: 88 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C
13: 77 percent / MsCl, Et3N / CH2Cl2 / 16 h / Ambient temperature
14: 75 percent / MnO2 / CHCl3 / 6 h / Heating
View Scheme
参考文献
Ishibashi, Yasuharu; Ohba, Shigeru; Nishiyama, Shigeru; Yamamura, Shosuke
Tetrahedron Letters, 1996 , vol. 37, # 17 p. 2997 - 3000
