7-氧代-4,7-二氢吡唑并[1,5-a]嘧啶-6-羧酸乙酯合成路线 （共 6 条）
反应条件
dowtherm A T=250°C; 2 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/76593 A1, 2009 ;
Location in patent: Page/Page column 50 ;
WO 2009/076593 A1
反应条件
in acetic acid T=120°C; 4.5 h;
参考文献
Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1043 - 1046
反应条件
T=200°C; 0.166667 h;
参考文献
Lager, Erik; Andersson, Pierre; Nilsson, Jakob; Pettersson, Ingrid; Nielsen, Elsebet stergaard; Nielsen, Mogens; Sterner, Olov; Liljefors, Tommy
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2526 - 2533
反应条件
1: 100 percent / aq. NaOH / ethanol / 3.5 h / 100 °C 2: 98 percent / Dowtherm A / 2 h / 250 °C View Scheme
参考文献
Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1043 - 1046
反应条件
sodium hydroxide in ethanol T=100°C; 3.5 h;
参考文献
Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1043 - 1046
反应条件
1.1: 100 percent / aq. NaOH / ethanol / 3.5 h / 100 °C
2.1: 98 percent / Dowtherm A / 2 h / 250 °C
3.1: NaH / dimethylformamide / 0 - 20 °C
3.2: 89 percent / dimethylformamide / 0.5 h / 20 °C
View Scheme
参考文献
Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C.
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1043 - 1046
