5-(羟基甲基)-3-苯基噁唑啉-2-酮合成路线 （共 9 条）
反应条件
hydrogen; Pd(OH)2/C in ethanol
T=55°C; 16 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/94265 A1, 2009 ;
Location in patent: Page/Page column 60 ;
WO 2009/094265 A1
反应条件
sodium methylate
4 h; Reflux;
参考文献
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CANNEY, Daniel, J.; BHANDARE, Richie, R.; BLASS, Benjamin, E.; ABOU-GHARBIA, Magid
Patent: WO2014/85413 A1, 2014 ;
Location in patent: Paragraph 00217 ;
反应条件
triethylamine; palladium dichloride in ethylene glycol dimethyl ether
P=2280 Torr; 72 h; Ambient temperature;
参考文献
Tam, Wilson
Journal of Organic Chemistry, 1986 , vol. 51, # 15 p. 2977 - 2981
反应条件
sodium methylate in water
参考文献
E. I. DuPont de Nemours and Company
Patent: US4461773 A1, 1984 ;
反应条件
copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane; potassium carbonate in 1,4-dioxane
Goldberg coupling; 15 h; Heating;
参考文献
Mallesham; Rajesh; Reddy, P Rajamohan; Srinivas; Trehan, Sanjay
Organic letters, 2003 , vol. 5, # 7 p. 963 - 965
反应条件
n-butyllithium in tetrahydrofuran
T=-78 - 20°C;
参考文献
Adibpour, Neda; Khalaj, Ali; Rajabalian, Saeed
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 19 - 24
反应条件
sodium
T=170 - 180°C; 1 h;
参考文献
Alimov,E.; Tulyaganov,S.R.
Journal of Organic Chemistry USSR (English Translation), 1972 , vol. 8, p. 431
Zhurnal Organicheskoi Khimii, 1972 , vol. 8, p. 429
反应条件
1: 2 h / 90 °C
2: sodium methylate / 4 h / |Reflux
View Scheme
参考文献
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CANNEY, Daniel, J.; BHANDARE, Richie, R.; BLASS, Benjamin, E.; ABOU-GHARBIA, Magid
Patent: WO2014/85413 A1, 2014 ;
反应条件
2: lipoprotein lipase, sodium hydroxyde / various solvent(s) / 6 h
View Scheme
参考文献
Hamaguchi, Shigeki; Yamamura, Hiroshi; Hasegawa, Junzo; Watanabe, Kiyoshi
Agricultural and Biological Chemistry, 1985 , vol. 49, # 5 p. 1509 - 1512
