1: phenyllithium With 3-butyl-1,1-dimethyl-1,3-dihydro-benzo[c][1,2]oxasilole in tetrahydrofuran; anhydrous butyl ether T=-78 - 20°C; 1 h; Inert atmosphere; 2: para-bromobenzonitrile With copper(l) iodide; dpca; palladium dichloride in tetrahydrofuran; anhydrous butyl ether T=20°C; 12 h; Inert atmosphere;
参考文献
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; HOYE, Adam, T.; KIM, Won-suk; MARTINEZ-SOLORIO, Dionicio; SMITH, Amos, B.; SANCHEZ, Luis; TONG, Rongbiao; NGUYEN, Minh, Huu
Patent: WO2013/185021 A2, 2013 ;
Location in patent: Paragraph 0049 ;
1: With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; tert-butylhypochlorite in dichloromethane T=20°C; 2 h; Inert atmosphere; 2: With ammonia; iodine in dichloromethane; water T=20°C; 2 h; Inert atmosphere;
1: PTAS With tetrabutyl ammonium fluoride in tetrahydrofuran; water T=20°C; 1 h; 2: para-chloro-benzonitrile With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water T=80°C; 3 h;
