2-[(二甲基氨基)甲基]-1-(3-甲氧基苯基)环己烷-1-醇合成路线 （共 12 条）
反应条件
sodium hydroxide in water T=20°C; 0.25 h;
参考文献
Syntrix Biosystems, Inc.; Zebala, John A.
Patent: US2013/11444 A1, 2013 ;
Location in patent: Paragraph 0210 ;
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
2: tetrahydrofuran View Scheme
参考文献
Evans, Graham R.; Fernandez, Paloma Diaz; Henshilwood, James A.; Lloyd, Steve; Nicklin, Chris
Organic Process Research and Development, 2002 , vol. 6, # 5 p. 729 - 737
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
参考文献
Blaney; Grigg; Rankovic; Thoroughgood
Tetrahedron Letters, 2000 , vol. 41, # 34 p. 6639 - 6642
反应条件
hydrogenchloride in diethyl ether Product distribution / selectivity;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 6-7; 8 ;
反应条件
hydrogenchloride in diethyl ether Product distribution / selectivity;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 6-7; 8 ;
反应条件
hydrogenchloride in diethyl ether Product distribution / selectivity;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 6-7; 8 ;
反应条件
hydrogenchloride in diethyl ether Product distribution / selectivity;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 6-7; 8 ;
