(S)-2-氯-2-苯基乙酸合成路线 （共 15 条）
反应条件
dihydrogen peroxide; lithium hydroxide hydrate in tetrahydrofuran; water T=0°C; enantioselective reaction;
参考文献
Hamashima, Yoshitaka; Nagi, Tatsuya; Shimizu, Ryo; Tsuchimoto, Teruhisa; Sodeoka, Mikiko
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3675 - 3678
反应条件
recombinant nitrilase from Pseudomonas fluorescens EBC 191 in methanol; phosphate buffer T=25°C; pH=6; Title compound not separated from byproducts;
参考文献
Fernandes, Bruno C. M.; Mateo, Cesar; Kiziak, Christoph; Chmura, Andrzej; Wacker, Jan; Van Rantwijk, Fred; Stolz, Andreas; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 18 p. 2597 - 2603
反应条件
(R)-LBA(1) in dichloromethane T=-78°C; 0.166667 h; other ketene bis(trimethylsilyl)acetals; Product distribution;
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
1,1-dichlorocycloheptatriene; triethylamine in dichloromethane 1 h; Inert atmosphere;
参考文献
Nguyen, Thanh V.; Bekensir, Alp
Organic Letters, 2014 , vol. 16, # 6 p. 1720 - 1723
反应条件
phosphate buffer in ethanol T=30°C; 12 h; Anr4 cell line; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Yamazaki, Yoshimitsu; Yusa, Shiro; Kageyama, Yu-Ichi; Tsue, Hirohito; Hirao, Ken-Ichi; Okuno, Hiroaki
Journal of Fluorine Chemistry, 1996 , vol. 79, # 2 p. 167 - 171
参考文献
Yamazaki, Yoshimitsu; Yusa, Shiro; Kageyama, Yu-Ichi; Tsue, Hirohito; Hirao, Ken-Ichi; Okuno, Hiroaki
Journal of Fluorine Chemistry, 1996 , vol. 79, # 2 p. 167 - 171
参考文献
Mc Kenzie; Clough
Journal of the Chemical Society, 1909 , vol. 95, p. 780,789
参考文献
McKenzie; Smith
Journal of the Chemical Society, 1923 , vol. 123, p. 1968,1975, 1977
参考文献
McKenzie; Smith
Chemische Berichte, 1925 , vol. 58, p. 900,908
反应条件
1: PCl5 / 160 °C 2: water View Scheme
参考文献
Walden
Chemische Berichte, 1895 , vol. 28, p. 1295,1296
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1898 , vol. 30, p. 535,538
