(E)-1-苯基-3-(2-噻吩基)-2-丙烯-1-酮合成路线 （共 10 条）
反应条件
1: benzaldehyde With potassium hydroxide in methanol; water T=0°C; 0.166667 h; 2: thiophene-2-carbaldehyde in methanol; water T=0°C; 3 h;
参考文献
YEUNGNAM EDUCATIONAL FOUNDATION
Patent: WO2005/121129 A1, 2005 ;
Location in patent: Page/Page column 15 ;
反应条件
sodium hydroxide in ethanol 2 h;
参考文献
El-Rayyes
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 2 p. 415 - 432
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=-78°C; 0.166667 h; 2: With sulfuric acid in ethylene glycol dimethyl ether T=-78°C; 0.166667 h;
参考文献
Yoshizawa, Kazuhiro; Shioiri, Takayuki
Tetrahedron Letters, 2006 , vol. 47, # 28 p. 4943 - 4945
反应条件
potassium carbonate; triphenylphosphine in methanol T=150°C; Wittig reaction; 5 h;
参考文献
Westman, Jacob
Organic Letters, 2001 , vol. 3, # 23 p. 3745 - 3747
反应条件
hydrogenchloride; n-butyllithium; acetic acid 1) -78 deg C, 2 h, THF, hexane, 2) H2O, methanol, room temperature, 2 h; Yield given. Multistep reaction;
参考文献
Matsumura, Noboru; Kunugihara, Akira; Yoneda, Shigeo
Tetrahedron Letters, 1983 , vol. 24, # 31 p. 3239 - 3242
反应条件
methanol; sodium methylate
参考文献
Grischkewitsch-Trochimowski; Mazurewitsch
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1912 , vol. 44, p. 575
Chem. Zentralbl., 1912 , vol. 83, # II p. 1561
参考文献
El-Sayed, Ragab A.
Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 5 p. 1143 - 1151
反应条件
hydrazine hydrate
0.25 h; Heating;
参考文献
El-Rayyes, Nizar R.; Hovakeemian, George H.; Hmoud, Hayat S.
Journal of Chemical and Engineering Data, 1984 , vol. 29, # 2 p. 225 - 229
反应条件
1: diethyl ether; benzene
View Scheme
参考文献
Dmitrieva,G.V. et al.
Journal of Organic Chemistry USSR (English Translation), 1977 , vol. 13, p. 378 - 382
Zhurnal Organicheskoi Khimii, 1977 , vol. 13, p. 419 - 424
参考文献
Ried; Stahlhofen
Chemische Berichte, 1957 , vol. 90, p. 815,822
