2-氨基-5,6-二甲基苯并咪唑合成路线 （共 7 条）
反应条件
in methanol; water T=50°C; 1 h;
参考文献
Frei, Reto; Breitbach, Anthony S.; Blackwell, Helen E.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 21 p. 5226 - 5229
反应条件
1: zinc; aqueous ethanolic NaOH 2: water View Scheme
参考文献
Dellweg et al.
Biochemische Zeitschrift, 1956 , vol. 327, p. 422,447
反应条件
copper dichloride; sodium nitrite in water T=20 - 100°C; 2 h;
参考文献
NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan
Patent: WO2012/117062 A1, 2012 ;
Location in patent: Page/Page column 38; 39 ;
反应条件
potassium hydroxide in ethanol 1.) 25 deg C, 2 h, 2.) reflux, 4 h;
参考文献
Vlaovic, Djordje; Canadanovic-Brunet, Jasna; Balaz, Jelica; Juranic, Ivan; Djokovic, Dejan; Mackenzie, Kenneth
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 2.3.4. p. 199 - 206
参考文献
Eli Lilly and Company
Patent: US4000275 A1, 1976 ;
反应条件
210 deg C, 1.5 h; ethanol, reflux, 5 min.;
参考文献
Daidone; Raffa; Plescia; Matera; Caruso; Leone; Amico-Roxas
Farmaco, 1989 , vol. 44, # 5 p. 465 - 473
反应条件
potassium hydroxide; hydroxylamine-o-sulphonic acid
T=25°C; 24 h;
参考文献
Vlaovic, Djordje; Canadanovic-Brunet, Jasna; Balaz, Jelica; Juranic, Ivan; Djokovic, Dejan; Mackenzie, Kenneth
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 2.3.4. p. 199 - 206
