2,6-二甲氧基-3-甲基-9H-咔唑合成路线 （共 11 条）
反应条件
copper diacetate; palladium diacetate in N,N-dimethyl-formamide
T=130°C; 1 h; Sealed tubeMicrowave irradiation;
参考文献
Sridharan, Vellaisamy; Antonia Martin; Carlos Menendez
European Journal of Organic Chemistry, 2009 , # 27 p. 4614 - 4621
反应条件
1: 81.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / toluene / 3 h / 160 °C / microwave irradiation
2: 61.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / dioxane / 18 h / Heating
View Scheme
参考文献
Bedford, Robin B.; Betham, Michael
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9403 - 9410
反应条件
1: 81 percent / BH3*SMe2 / chlorobenzene / 21 h / 80 - 130 °C
2: 81.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / toluene / 3 h / 160 °C / microwave irradiation
3: 61.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / dioxane / 18 h / Heating
View Scheme
参考文献
Bedford, Robin B.; Betham, Michael
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9403 - 9410
反应条件
1: 81.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / toluene / 3 h / 160 °C / microwave irradiation
2: 61.5 percent / NaOtBu; Pd(OAc)2; [HP-t-Bu3][BF4] / dioxane / 18 h / Heating
View Scheme
参考文献
Bedford, Robin B.; Betham, Michael
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9403 - 9410
反应条件
in methanol
T=0°C; 16 h;
参考文献
Bhattacharyya, P.; Chakrabartty, P. K.; Chowdhury, B. K.
Phytochemistry (Elsevier), 1985 , vol. 24, # 4 p. 882 - 883
反应条件
1: copper diacetate; octane-1-acetic acid; 2,6-dimethylpyridine / toluene / 24 h / 20 °C
2: palladium diacetate; potassium carbonate / dimethyl sulfoxide / 5 h / 130 °C / |Inert atmosphere; |Sealed tube
3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 65 °C
View Scheme
参考文献
Rasheed, Sk.; Rao, D. Nageswar; Reddy, K. Ranjith; Aravinda; Vishwakarma, Ram A.; Das, Parthasarathi
RSC Advances, 2014 , vol. 4, # 10 p. 4960 - 4969
反应条件
1: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
2: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
反应条件
1: K2CO3 / acetone / 4 h / Heating
2: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
3: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
反应条件
1: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
2: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
反应条件
1: PhCH2NMe3(1+)*Br3(1-) / CH2Cl2; methanol / 5 h / Ambient temperature
2: K2CO3 / acetone / 4 h / Heating
3: 1.) t-BuLi, 2.) Bu3SnCl, 3.) Pd(PPh3)2Cl2
4: 99 percent / KNH2 / liquid ammonia / 3 h / -33 °C
View Scheme
参考文献
Iwao, Masatomo; Takehara, Hirokazu; Furukawa, Sunao; Watanabe, Mitsuaki
Heterocycles, 1993 , vol. 36, # 7 p. 1483 - 1488
