反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.08 h / 0 °C 1.2: 0.5 h / 0 °C 2.1: toluene-4-sulfonic acid / methanol / 24 h / |Reflux; |Inert atmosphere 3.1: methyl lithium LiBr complex / tert-butyl methyl ether; diethyl ether / 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; Van Der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8432 - 8454
