Z-甘氨酸 N-琥珀酰亚胺酯合成路线 （共 18 条）
反应条件
dicyclohexyl-carbodiimide in ethylene glycol dimethyl ether T=0°C;
参考文献
Detsi, Anastasia; Micha-Screttas, Maria; Igglessi-Markopoulou, Olga
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2443 - 2449
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
参考文献
Ajinomoto Co., Inc.
Patent: US3933783 A1, 1976 ;
反应条件
pyridine in acetonitrile
参考文献
Griffin, Martin; Mongeot, Alexandre; Collighan, Russell; Saint, Robert E.; Jones, Richard A.; Coutts, Ian G.C.; Rathbone, Daniel L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5559 - 5562
反应条件
1: 2N aq NaOH 2: N,N'-diisopropylcarbodiimide View Scheme
参考文献
Hayashi, Takashi; Asai, Tomohito; Ogoshi, Hisanobu
Tetrahedron Letters, 1997 , vol. 38, # 17 p. 3039 - 3042
参考文献
Rzeszotarska; Nadolska; Tarnawski
1981 , vol. No. 7, p. 1294 - 1302
反应条件
triethylamine in dichloromethane Ambient temperature;
参考文献
Geurts, Muriel; Poupaert, Jacques H.; Scriba, Gerhard K. E.; Lambert, Didier M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 1 p. 24 - 30
反应条件
pyridine; 1-hydroxy-pyrrolidine-2,5-dione; formic acid; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 1.) reflux, 4 min; 2.) r.t., overnight;
参考文献
Kinoshita, Hideki; Inomata, Katsuhiko; Kameda, Takuo; Kotake, Hiroshi
Chemistry Letters, 1985 , p. 515 - 518
反应条件
1: 50 percent / Et3N / tetrahydrofuran; H2O / 20 °C 2: 100 percent / HOBT / CH2Cl2 3: 58 percent / TEA / tetrahydrofuran; dimethylformamide; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 4 p. 664 - 674
