4-氨基-2,6-二氯-3-硝基吡啶嘧啶合成路线 （共 19 条）
反应条件
sulfuric acid T=100°C; 1 h;
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
Location in patent: Page/Page column 51; 53 ;
反应条件
1: With sulfuric acid T=-5°C; 2: With nitric acid in water T=0 - 80°C; 3: With ammonia in water pH=~ 4; Cooling with acetone-dry ice;
参考文献
LIGAND PHARMACEUTICALS INC.; COLE, Andrew; MCGUINNESS, Brian, F.; SHAO, Yuefei; DONG, Guizhen; HENDERSON, Ian
Patent: WO2010/8775 A1, 2010 ;
Location in patent: Page/Page column 24 ;
WO 2010/008775 A1
反应条件
1: CF3COOH; aq. H2O2 / 6.5 h / Heating 2: HNO3; H2SO4 / 160 °C 3: AcOH; Fe / Heating 4: HNO3; H2SO4 / 20 °C 5: H2SO4 / 100 °C View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
反应条件
1: HNO3; H2SO4 / 160 °C 2: AcOH; Fe / Heating 3: HNO3; H2SO4 / 20 °C 4: H2SO4 / 100 °C View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
反应条件
1: AcOH; Fe / Heating 2: HNO3; H2SO4 / 20 °C 3: H2SO4 / 100 °C View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran; water / 0.33 h / 25 °C 2: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 3: sodium azide / water; acetone / 0.03 h / 25 °C 4: trifluoroacetic acid / benzene / 21 h / 90 °C 5: potassium carbonate / methanol / 7.5 h / 25 °C 6: sulfuric acid; nitric acid / -5 °C 7: sulfuric acid / 1 h / 0 - 100 °C View Scheme
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
反应条件
1: trichlorophosphate / 24 h / 130 °C 2: lithium hydroxide hydrate / tetrahydrofuran; water / 0.33 h / 25 °C 3: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 4: sodium azide / water; acetone / 0.03 h / 25 °C 5: trifluoroacetic acid / benzene / 21 h / 90 °C 6: potassium carbonate / methanol / 7.5 h / 25 °C 7: sulfuric acid; nitric acid / -5 °C 8: sulfuric acid / 1 h / 0 - 100 °C View Scheme
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
反应条件
1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 2: sodium azide / water; acetone / 0.03 h / 25 °C 3: trifluoroacetic acid / benzene / 21 h / 90 °C 4: potassium carbonate / methanol / 7.5 h / 25 °C 5: sulfuric acid; nitric acid / -5 °C 6: sulfuric acid / 1 h / 0 - 100 °C View Scheme
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
反应条件
1: sodium azide / water; acetone / 0.03 h / 25 °C 2: trifluoroacetic acid / benzene / 21 h / 90 °C 3: potassium carbonate / methanol / 7.5 h / 25 °C 4: sulfuric acid; nitric acid / -5 °C 5: sulfuric acid / 1 h / 0 - 100 °C View Scheme
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
反应条件
1: trifluoroacetic acid / benzene / 21 h / 90 °C 2: potassium carbonate / methanol / 7.5 h / 25 °C 3: sulfuric acid; nitric acid / -5 °C 4: sulfuric acid / 1 h / 0 - 100 °C View Scheme
参考文献
Ehmke, Veronika; Winkler, Edwin; Banner, David W.; Haap, Wolfgang; Schweizer, W. Bernd; Rottmann, Matthias; Kaiser, Marcel; Freymond, Celine; Schirmeister, Tanja; Diederich, Francois
ChemMedChem, 2013 , vol. 8, # 6 p. 967 - 975
