四氢-(2H)-1,4-硫氮杂革-5-酮合成路线

1072-72-6四氢噻喃-4-酮→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Takeda Chemical Industries, Ltd.
Patent: EP1486490 A1, 2004 ;
Location in patent: Page 46 ;

6309-59-7四氢噻喃-4-酮肟+98-59-9对甲苯磺酰氯→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Merck and Co., Inc.
Patent: US6043358 A1, 2000 ;

1072-72-6四氢噻喃-4-酮→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮+101184-85-4

参考文献

Pharmacia and Upjohn Company
Patent: US6248739 B1, 2001 ;

6309-59-7四氢噻喃-4-酮肟→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Grob,C.A.; Ide,J.
Helvetica Chimica Acta, 1974 , vol. 57, p. 2562 - 2571

55118-45-1→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Caldwell, Charles G.; Chen, Ping; Hagmann, William K.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Kelly, Theresa M.; Grant, Stephan K.; Wong, Kenny K.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5907 - 5911

1369959-37-4+60-23-1半胱胺→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Yang, Xiaofeng; Guo, Yixing; Strongin, Robert M.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 14 p. 2739 - 2741,3

151-56-4乙烯亚胺+2935-90-23-巯基丙酸甲酯→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Jakob,F.; Schlack,P.
Chemische Berichte, 1963 , vol. 96, p. 88 - 92

292638-85-8丙烯酸甲酯+60-23-1半胱胺→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Jakob,F.; Schlack,P.
Chemische Berichte, 1963 , vol. 96, p. 88 - 92

1362772-43-7+60-23-1半胱胺→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮+6265-93-6

参考文献

Yang, Xiaofeng; Guo, Yixing; Strongin, Robert M.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10690 - 10693

151-56-4乙烯亚胺+5466-06-83-巯基丙酸乙酯→2896-98-2四氢-(2H)-1,4-硫氮杂革-5-酮

参考文献

Arya,V.P. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15, p. 720 - 726