3-甲基-1-苯基-2-丁酮合成路线 （共 74 条）
反应条件
(i) N-chloro-succinimide, NaHCO3, MeOH, (ii) aq. HCl; Multistep reaction;
参考文献
Tetrahedron Letters, , # 44 p. 3797 - 3800
反应条件
5 Pd/C; 2-(trimethylsilyl)ethyl 4-(biphenyl-4-yl)-2,2-dimethyl-3-oxobutanoate; hydrogen; triethylamine in ethyl acetate T=20°C; P=750.075 Torr; 53 h;
参考文献
Knobloch, Eva; Brueckner, Reinhard
Synthesis, 2008 , # 14 SPEC. ISS. art. no. C02108SS, p. 2229 - 2246
反应条件
vanadium(II) chloride in tetrahydrofuran 1 h; Heating;
参考文献
Olah, George A.; Chao, Yah-Lih; Arvanaghi, Massoud; Prakash, G. K. Surya
Synthesis, 1981 , # 6 p. 476
反应条件
(i) KNH2, liq. NH3, (ii) (irradiation), /BRN= 1236661/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 38, p. 3020 - 3025
反应条件
aluminium amalgam in tetrahydrofuran; water 4 h; Heating; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 443 - 453
反应条件
1: With titanium tetrachloride; tert-butylamine; aniline in toluene T=105°C; 22 h; 2: With water; silica gel in dichloromethane; toluene T=20°C; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 16 p. 6149 - 6153
反应条件
1: NaH / diethyl ether; ethanol / 2 h / Heating 2: pyridine 3: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C 4: pyridine 5: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating 6: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature 7: CrO3 / acetone / 0.33 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 443 - 453
反应条件
1: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C 2: pyridine 3: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating 4: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature 5: CrO3 / acetone / 0.33 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 443 - 453
反应条件
1: pyridine 2: 28 percent / LDA / tetrahydrofuran / 1.) 30 min, -78 deg C, 2.) 30 min, 0 deg C 3: pyridine 4: 82 percent / SO2Cl2 / CH2Cl2 / 2 h / Heating 5: H2 / 10percent Pd/C / methanol / 20 h / Ambient temperature 6: CrO3 / acetone / 0.33 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 443 - 453
反应条件
1: With Montmorillonite KSF; 2-(trimethylsilyl)ethyl 4-(biphenyl-4-yl)-2,2-dimethyl-3-oxobutanoate in acetonitrile T=80°C; 3 h; 2: With triethylamine in acetonitrile T=20°C; 1 h;
参考文献
Knobloch, Eva; Brueckner, Reinhard
Synthesis, 2008 , # 14 SPEC. ISS. art. no. C02108SS, p. 2229 - 2246
