3’-氯-4’-羟基苯乙酮合成路线 （共 16 条）
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-benzene T=20 - 100°C; Fries Phenol Ester Rearrangement; 5 h;
参考文献
Shah; Parikh
Journal of the Indian Chemical Society, 1959 , vol. 36, p. 784
反应条件
aluminium trichloride in carbon disulfide 1.) RT, 1 h, 2.) reflux, 12 h;
参考文献
Leclerc, Gerard; Bizec, Jean Claude; Bieth, Nicole; Schwartz, Jean
Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 738 - 744
反应条件
aluminium trichloride T=120°C; Fries rearrangement;
参考文献
Conway, Stuart J; Miller, Jacqueline C; Howson, Patrick A; Clark, Barry P; Jane, David E
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 777 - 780
反应条件
1: in acetonitrile T=80°C; 0.166667 h; 2: With N-chloro-succinimide in acetonitrile T=80°C; 8 h; regioselective reaction;
参考文献
Singh, Parvinder Pal; Thatikonda, Thanusha; Kumar, K. A. Aravinda; Sawant, Sanghapal D.; Singh, Baldev; Sharma, Amit Kumar; Sharma; Singh, Deepika; Vishwakarma, Ram A.
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5823 - 5828
反应条件
1: 79 percent / aq. NaOH 2: 59 percent / AlCl3 / 120 °C View Scheme
参考文献
Gabriel, Gabriel; Pickles, Robert; Tyman, John H. P.
Journal of Chemical Research, Miniprint, 1989 , # 11 p. 2713 - 2739
反应条件
N-chloro-succinimide T=80°C; 10 h; regioselective reaction;
参考文献
Singh, Parvinder Pal; Thatikonda, Thanusha; Kumar, K. A. Aravinda; Sawant, Sanghapal D.; Singh, Baldev; Sharma, Amit Kumar; Sharma; Singh, Deepika; Vishwakarma, Ram A.
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5823 - 5828
反应条件
1: pyridine / dichloromethane / 4 h / 20 - 25 °C 2: AlCl3, aluminium chloride / 1,2-dichloro-benzene / 5 h / 20 - 100 °C View Scheme
参考文献
Fumagalli, Laura; Pallavicini, Marco; Budriesi, Roberta; Gobbi, Marco; Straniero, Valentina; Zagami, Michael; Chiodini, Giuseppe; Bolchi, Cristiano; Chiarini, Alberto; Micucci, Matteo; Valoti, Ermanno
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 184 - 191
反应条件
pyridine hydrochloride
参考文献
Royer,R. et al.
Bulletin de la Societe Chimique de France, 1973 , p. 611 - 615
反应条件
aluminium trichloride
参考文献
Nguyen-Hoan; Buu-Hoi
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 1363
反应条件
sodium hydroxide; potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Pfizer Inc.
Patent: US6531492 B1, 2003 ;
