6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯合成路线 （共 24 条）
反应条件
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 20 - 25 °C 2: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -75 - -10 °C View Scheme
反应条件
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 20 - 25 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 2.33 h / -75 - -10 °C View Scheme
反应条件
water; trifluoroacetic acid T=30 - 40°C;
参考文献
WO2012/172564 A1, ;
Page/Page column 22-23 ;
反应条件
1: With hydrogenchloride; water in methanol T=25°C; 2: With water; sodium hydroxide in methanol T=30°C; 7.5 - 8.5 h; 3: With hydrogenchloride in water pH=3.5 - 4;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; PATEL, Dhimant Jasubhai; RUPAPARA, Mahesh Laljibhai; KHERA, Brij
Patent: WO2012/73256 A1, 2012 ;
Location in patent: Page/Page column 22 ;
