in toluene T=60°C; 3 h;

1: methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate With diisobutylaluminium hydride in toluene T=-10 - 0°C; 2.5 h; 2: With hydrogenchloride in methanol; water; acetonitrile T=0 - 40°C; 2.83333 h; 3: ethoxydiphenylphosphane With phosphorus tribromide more than 3 stages;

sodium iodide; sodium hydrogensulfite in trans-decahydronaphthalene; ethyl acetate; mineral oil

tetrabutyl-ammonium chloride in water; toluene

tetrabutylammomium bromide in water; toluene

1: diisobutylaluminium hydride / toluene / -78 - 0 °C / Inert atmosphere 2: triethylamine; methanesulfonyl chloride / dichloromethane / 5 h / 0 - 25 °C 3: hydrogen bromide / water / 15 h / 80 °C 4: 9 h / 90 - 100 °C View Scheme

1: hydrogen bromide / water / 15 h / 80 °C 2: 9 h / 90 - 100 °C View Scheme

1: sodium hexamethyldisilazane / tetrahydrofuran / -40 - 5 °C / Inert atmosphere 2: sulfuric acid / acetonitrile / 3 h / 50 - 60 °C View Scheme

1: N-[5-[(diphenylphosphinoyl)-methyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidindin-2-yl]-N-methyl-methanesulfonamide With sodium hexamethyldisilazane in tetrahydrofuran T=-76 - -74°C; 1.16667 h; 2: tert-butyl 3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexuronate in toluene T=-76 - 10°C; 2.08333 h;