(2-羟基苯基)-哌啶-1-甲酮合成路线 （共 10 条）
反应条件
water; sodium hydroxide in 1,4-dioxane
T=75°C; 3.5 h;
参考文献
OMahony, Gavin; Pitts, Andrew K.
Organic Letters, 2010 , vol. 12, # 9 p. 2024 - 2027
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78 - 20°C; anionic ortho-Fries rearrangement; Inert atmosphere;
参考文献
Assimomytis, Nikos; Sariyannis, Yiannis; Stavropoulos, Georgios; Tsoungas, Petros G.; Varvounis, George; Cordopatis, Paul
Synlett, 2009 , # 17 p. 2777 - 2782
反应条件
triethylamine in tetrahydrofuran
0.5 h;
参考文献
Katritzky, Alan R.; Singh, Sanjay K.; Cai, Chunming; Bobrov, Sergey
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3364 - 3374
反应条件
[bis(acetoxy)iodo]benzene; [Ru(p-cymene)(MesCO2)2]; trifluoroacetic acid; trifluoroacetic anhydride
T=120°C; 30 h;
参考文献
Thirunavukkarasu, Vedhagiri S.; Hubrich, Jonathan; Ackermann, Lutz
Organic Letters, 2012 , vol. 14, # 16 p. 4210 - 4213
反应条件
K[AuIIICl4]; potassium carbonate in water; acetonitrile
T=40°C; 12 h;
参考文献
Li, Gai-Li; Kung, Karen Ka-Yan; Wong, Man-Kin
Chemical Communications, 2012 , vol. 48, # 34 p. 4112 - 4114
反应条件
1: 92 percent / SOCl2 / tetrahydrofuran / 2 h / 20 °C
2: 94 percent / triethylamine / tetrahydrofuran / 0.5 h
View Scheme
参考文献
Katritzky, Alan R.; Singh, Sanjay K.; Cai, Chunming; Bobrov, Sergey
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3364 - 3374
参考文献
VanAllan
Journal of the American Chemical Society, 1947 , vol. 69, p. 2913
参考文献
Massarani
Farmaco, Edizione Scientifica, 1957 , vol. 12, p. 691,693
参考文献
Schotten
Chemische Berichte, 1888 , vol. 21, p. 2251
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
参考文献
Assimomytis, Nikos; Sariyannis, Yiannis; Stavropoulos, Georgios; Tsoungas, Petros G.; Varvounis, George; Cordopatis, Paul
Synlett, 2009 , # 17 p. 2777 - 2782
