L-天冬氨酸二苄酯 对甲苯磺酸盐合成路线 （共 9 条）
反应条件
in benzene 3.5 h; Heating;
参考文献
Bergmeier, Stephen C.; Cobas, Agustin A.; Rapoport, Henry
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2369 - 2376
反应条件
1: 1.) CuSO4, 5 M NaOH, 2.) EDTA / 1.) EtOH, 32 deg C, 1 h, 2.) H2O, 100 deg C, 10 min 2: 53 percent / conc. H2SO4 / 20 h / -25 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 2 p. 391 - 401
反应条件
sodium carbonate in 1,4-dioxane 18 h; Ambient temperature;
参考文献
Parr, Ian B.; Boehlein, Susan K.; Dribben, Anthony B.; Schuster, Sheldon M.; Richards, Nigel G. J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2367 - 2378
反应条件
1: 98 percent / CuCO3*Cu(OH)2 / ethanol; H2O / 2 h / 70 °C 2: 90 percent / Et3N / H2O; tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 9 p. 2369 - 2376
反应条件
1: 98 percent / CuCO3*Cu(OH)2 / ethanol; H2O / 2 h / 70 °C 2: 90 percent / Et3N / H2O; tetrahydrofuran / 12 h / Ambient temperature 4: HCl View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 9 p. 2369 - 2376
反应条件
hydrogen bromide in acetic acid
参考文献
Savrda; Bricas
Bulletin de la Societe chimique de France, 1968 , vol. 6, p. 2423 - 2429
反应条件
sodium carbonate in water
参考文献
MERCK and CO., INC.
Patent: WO2004/83173 A2, 2004 ;
Location in patent: Page 31 ;
WO 2004/083173 A2
反应条件
sodium hydroxide; ethylenediaminetetraacetic acid disodium salt; copper(II) sulfate 1.) ethanol, water, 25 deg C, 0.5 h, 2.) water; Yield given. Multistep reaction;
参考文献
Adlington, Robert M.; Baldwin, Jack E.; Catterick, David; Pritchard, Garcth J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 8 p. 855 - 866
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in dichloromethane
T=5°C;
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
