3-苯基-2(1H)-吡嗪酮合成路线 （共 16 条）
反应条件
1: POBr3 2: 4-methyl-pyridine View Scheme
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1956 , vol. 78, p. 2141,2144
反应条件
1: POCl3, PCl5 / 1 h / 160 °C 2: 49 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h 3: hydrazine hydrate / ethanol / 2 h / 140 °C 4: CuSO4*5H2O, / acetic acid; H2O / 1 h / Heating 5: 1 h / Heating 6: 10percent KOH / methanol / 1 h / Heating 7: POCl3, PCl5 / 1 h / 160 °C 8: 74 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h 9: POCl3 / 0.5 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
in 1,4-dioxane
T=50°C; 168000 h;
参考文献
Rombouts, Frederik J.R.; Van Den Bossche, Jeroen; Toppet, Suzanne M.; Compernolle, Frans; Hoornaert, Georges J.
Tetrahedron, 2003 , vol. 59, # 26 p. 4721 - 4731
反应条件
1: POCl3
2: methanol
3: aqueous H2O2; acetic acid
4: POCl3
5: aqueous HCl; acetic acid
6: POCl3 / 170 °C
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
参考文献
American Cyanamid Company
Patent: US4402958 A1, 1983 ;
参考文献
Sato, Nobuhiro; Narita, Nobuhiko
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 783 - 786
