3-苯基-2(1H)-吡嗪酮合成路线 （共 16 条）
反应条件
sodium hydroxide in methanol; water T=-20°C; 2 h; Yield given;
参考文献
Baertschi; Dorman; Occolowitz; Spangle; Collins; Wildfeuer; Lorenz
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 6 p. 622 - 626
反应条件
1: NH3 / CH2Cl2 / 0.5 h / -40 °C 2: 20percent NaOH / methanol; H2O / 2 h / -20 °C View Scheme
参考文献
Baertschi; Dorman; Occolowitz; Spangle; Collins; Wildfeuer; Lorenz
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 6 p. 622 - 626
反应条件
potassium hydroxide in methanol 1 h; Heating;
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 34 percent / KOH / ethanol / 5 h / Heating 2: 76 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 1) r.t., overnight, 2) reflux, 2 h 3: 1 h / Heating 4: 10percent KOH / methanol / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 76 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 1) r.t., overnight, 2) reflux, 2 h 2: 1 h / Heating 3: 10percent KOH / methanol / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: hydrazine hydrate / ethanol / 2 h / 140 °C 2: CuSO4*5H2O, / acetic acid; H2O / 1 h / Heating 3: 1 h / Heating 4: 10percent KOH / methanol / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 1 h / Heating 2: 10percent KOH / methanol / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 1 h / Heating 2: 10percent KOH / methanol / 1 h / Heating View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
hydrogenchloride 1440 h; Ambient temperature; Mechanism;
参考文献
Baertschi; Dorman; Occolowitz; Spangle; Collins; Wildfeuer; Lorenz
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 6 p. 622 - 626
反应条件
1: POCl3, PCl5 / 1 h / 160 °C 2: 49 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h 3: hydrazine hydrate / ethanol / 2 h / 140 °C 4: CuSO4*5H2O, / acetic acid; H2O / 1 h / Heating 5: 1 h / Heating 6: 10percent KOH / methanol / 1 h / Heating 7: POCl3, PCl5 / 1 h / 160 °C View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
