5-甲氧基-2-甲基-3-吲哚乙酸合成路线 （共 45 条）
反应条件
1: sodium acetate / dimethylformamide / 2 h / Heating 2: 1.) sodium hydride / 1.) DME, 0 deg C, 10 min., 2.) DME, r.t., 3 h 4: 59 percent / conc. sulfuric acid / H2O / 6 h / Heating View Scheme
参考文献
Merour; Coadou; Tatibouet
Synthesis, 1982 , vol. No. 12, p. 1053 - 1056
反应条件
1: 1.) sodium hydride / 1.) DME, 0 deg C, 10 min., 2.) DME, r.t., 3 h 3: 59 percent / conc. sulfuric acid / H2O / 6 h / Heating View Scheme
参考文献
Merour; Coadou; Tatibouet
Synthesis, 1982 , vol. No. 12, p. 1053 - 1056
反应条件
1: 59 percent / aq. potassium hydroxide, potassium carbonate, Cu2Br2 / 5 h / 160 °C 2: sodium acetate / dimethylformamide / 2 h / Heating 3: 1.) sodium hydride / 1.) DME, 0 deg C, 10 min., 2.) DME, r.t., 3 h 5: 59 percent / conc. sulfuric acid / H2O / 6 h / Heating View Scheme
参考文献
Merour; Coadou; Tatibouet
Synthesis, 1982 , vol. No. 12, p. 1053 - 1056
反应条件
sodium hydroxide; sodium lauryl sulfate T=25°C; equilibrium constant for substrate binding; further reagent: hexadecyltrimethylammonium bromide; Rate constant;
参考文献
Matos, C.; Chaimovich, H.; Lima, J. L. F. C.; Cuccovia, I. M.; Reis, S.
Journal of Pharmaceutical Sciences, 2001 , vol. 90, # 3 p. 298 - 309
反应条件
2: 59 percent / conc. sulfuric acid / H2O / 6 h / Heating View Scheme
参考文献
Merour; Coadou; Tatibouet
Synthesis, 1982 , vol. No. 12, p. 1053 - 1056
反应条件
1: 42 percent / alumina (neutral) 2: 73 percent / Zn, HOAc / 2 h / 100 °C 3: 91 percent / 6 M NaOH / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Ishibashi, Hiroyuki; Mita, Naoki; Matsuba, Naoko; Kubo, Tomoko; Nakanishi, Mariko; Ikeda, Masazumi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 21 p. 2821 - 2826
反应条件
1: 73 percent / Zn, HOAc / 2 h / 100 °C 2: 91 percent / 6 M NaOH / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Ishibashi, Hiroyuki; Mita, Naoki; Matsuba, Naoko; Kubo, Tomoko; Nakanishi, Mariko; Ikeda, Masazumi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 21 p. 2821 - 2826
反应条件
anhydrous tetramethylammonium chloride in ethanol electrolysis at a controlled potential; mercury working electrode; graphite as the auxiliary electrode;
参考文献
Boneva, A. S.; Loginova, N. F.; Filippova, T. M.; Mishchenko, V. V.; Bekker, A. R.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 12 p. 863 - 871
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 12 p. 1494 - 1502
反应条件
anhydrous tetramethylammonium chloride in ethanol electrolysis at a controlled potential, pH 5.0; mercury working electrode; graphite as the auxiliary electrode;
参考文献
Boneva, A. S.; Loginova, N. F.; Filippova, T. M.; Mishchenko, V. V.; Bekker, A. R.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 12 p. 863 - 871
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 12 p. 1494 - 1502
反应条件
sodium hydroxide in acetonitrile T=25°C; Rate constant;
参考文献
Cipiciani; Ebert; Linda; Rubessa; Savelli
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 9 p. 1075 - 1076
