5-甲氧基-2-甲基-3-吲哚乙酸合成路线 （共 45 条）
反应条件
1: With sodium methylate in methanol 72 h; Inert atmosphere; 2: With hydrogenchloride in water pH=Ca. 1; Inert atmosphere;
参考文献
Scholz, Matthias; Blobaum, Anna L.; Marnett, Lawrence J.; Hey-Hawkins, Evamarie
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4830 - 4837
反应条件
mouse microsomes in aq. phosphate buffer T=37°C; pH=7.4; 20 h; Enzymatic reaction;
参考文献
Xie, Gang; Zhou, Dingying; Cheng, Ka-Wing; Wong, Chi C.; Rigas, Basil
Biochemical Pharmacology, 2013 , vol. 85, # 8 p. 1195 - 1202
反应条件
glucose-6-phosphate dehydrogenase; G-6-P; NADP; magnesium chloride in aq. phosphate buffer T=37°C; pH=7.4; 3 h; Enzymatic reaction; TimeReagent/catalyst;
参考文献
Xie, Gang; Zhou, Dingying; Cheng, Ka-Wing; Wong, Chi C.; Rigas, Basil
Biochemical Pharmacology, 2013 , vol. 85, # 8 p. 1195 - 1202
反应条件
glucose-6-phosphate dehydrogenase; G-6-P; NADP; magnesium chloride in aq. phosphate buffer T=37°C; pH=7.4; 0.333333 h; Enzymatic reaction; TimeReagent/catalyst;
参考文献
Xie, Gang; Zhou, Dingying; Cheng, Ka-Wing; Wong, Chi C.; Rigas, Basil
Biochemical Pharmacology, 2013 , vol. 85, # 8 p. 1195 - 1202
反应条件
sodium hydroxide in ethanol 3 h; Ambient temperature;
参考文献
Ishibashi, Hiroyuki; Mita, Naoki; Matsuba, Naoko; Kubo, Tomoko; Nakanishi, Mariko; Ikeda, Masazumi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 21 p. 2821 - 2826
反应条件
sulfuric acid in acetonitrile Fischer indole reaction; 24 h; Heating;
参考文献
Campos, Kevin R.; Woo, Jacqueline C. S.; Lee, Sandra; Tillyer, Richard D.
Organic Letters, 2004 , vol. 6, # 1 p. 79 - 82
反应条件
sulfuric acid in water 6 h; Heating;
参考文献
Merour; Coadou; Tatibouet
Synthesis, 1982 , vol. No. 12, p. 1053 - 1056
反应条件
hydrogenchloride Behandeln des Reaktionsprodukts mit wss.-aethanol. NaOH;
参考文献
Shaw
Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320
Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
反应条件
1: 1.) CH3COONa, 1 M CH3COOH, 2.) H2SO4 / 2.) EtOH, reflux, 3 h 2: 6 M NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1.) CH3COONa, 1 M CH3COOH, 2.) H2SO4 / 2.) EtOH, reflux, 3 h 2: 6 M NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
