(4-氯苯甲酰基)乙酸乙酯合成路线 （共 43 条）
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; manganese (II) chloride in ethyl acetate T=0 - 20°C; 18 h; Heating / reflux; 2: 4-chloro-benzoyl chloride in ethyl acetate T=0 - 20°C; 18 h;
参考文献
GLAXOSMITHKLINE LLC; WALKER, Jill; VOITENLEITNER, Christian
Patent: WO2013/25992 A1, 2013 ;
Location in patent: Page/Page column 48-49 ;
反应条件
sodium hydride in diethyl ether T=35 - 40°C;
参考文献
Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 272 - 284
反应条件
bis-triphenylphosphine-palladium(II) chloride in neat (no solvent) T=20°C; 3 h;
参考文献
Chen, Shufeng; Yuan, Fang; Zhao, Haiying; Li, Baoguo
RSC Advances, 2013 , vol. 3, # 31 p. 12616 - 12620
反应条件
1: ethyl acetoacetate With sodium hydride in tetrahydrofuran T=20°C; 0.666667 h; 2: (1H-1,2,3-benzotriazol-1-yl)(4-chlorophenyl)methanone in tetrahydrofuran T=20°C; 14 h; 3: With ammonium hydroxide; ammonium chloride in tetrahydrofuran; water 1 h; Heating;
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Wilkerson, Chavon R.; Hall, C. Dennis; Akhmedov, Novruz G.
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6617 - 6622
反应条件
1: ethyl acetate With lithium diisopropyl amide in diethyl ether T=-78°C; Inert atmosphere; 2: 4-chloro-benzoyl chloride in diethyl ether T=-78 - 20°C; Inert atmosphere;
参考文献
Lethu, Sebastien; Ginisty, Maryon; Bosc, Damien; Dubois, Joelle
Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6205 - 6208
反应条件
niobium pentachloride in dichloromethane T=27°C; 4 h;
参考文献
Yadav; Subba Reddy; Eeshwaraiah; Reddy
Tetrahedron, 2005 , vol. 61, # 4 p. 875 - 878
反应条件
potassium tert-butylate in carbonic acid diethyl ester
参考文献
BASF Aktiengesellschaft
Patent: US5744426 A1, 1998 ;
反应条件
dichromic acid in diethyl ether T=0 - 25°C; 4 h;
参考文献
Thakur, Vinay V.; Nikalje, Milind D.; Sudalai
Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 581 - 586
反应条件
pyridine; hydrogenchloride; ammonia in tetrahydrofuran; methanol; ethyl acetate; mineral oil; carbonic acid diethyl ester
参考文献
Ciba-Geigy Corporation
Patent: US4028381 A1, 1977 ;
反应条件
lt;(η5-C5H5)Fe(CO)2(THF)gt;+lt;BF4gt;- in dichloromethane T=0°C; 8 h;
参考文献
Mahmood, Syed J.; Hossain, M. Mahmun
Journal of Organic Chemistry, 1998 , vol. 63, # 10 p. 3333 - 3336
