1H-1,2,3-三氮唑合成路线 （共 105 条）
反应条件
trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide; caesium carbonate in N,N-dimethyl-formamide T=120 - 160°C; 0.416667 h; microwave;
参考文献
NOVARTIS AG; BADIGER, Sangamesh; BEHNKE, Dirk; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; OFNER, Silvio; PANDIT, Chetan; ROY, Bernard Lucien
Patent: WO2012/55888 A1, 2012 ;
Location in patent: Page/Page column 119-120 ;
WO 2012/055888 A1
反应条件
sodium methylate in methanol a.) -78 deg C, 1 h, b.) -78 deg C - 23 deg C, 1 h, c.) 23 deg C, 2 h;
参考文献
Kiselyov; Strekowski
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1361 - 1364
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 3 h;
参考文献
WO2008/98104 A1, ;
Page/Page column 94 ;
WO 2008/098104 A1
参考文献
WO2006/108591 A1, ;
Page/Page column 117-118 ;
WO 2006/108591 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Organic Letters, , vol. 12, # 20 p. 4632 - 4635
反应条件
sodium hydride 1.) acetonitrile, 0 deg C, 24 h, 2.) dichloromethane, a) from -25 to 20 deg C, 1 h, b) 20 deg C, 72 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Acta Chemica Scandinavica, , vol. 44, # 10 p. 1050 - 1057
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 13, p. 888,890
反应条件
bromine in water 1.) 40-45 deg C, 1 h, 2.) r.t., overnight;
参考文献
Iddon, Brian; Nicholas, Martin
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1341 - 1347
反应条件
sodium hypobromide; acetic acid
参考文献
Huettel, Rudolf; Schaefer, Otto; Jochum, Peter
Justus Liebigs Annalen der Chemie, 1955 , vol. 593, p. 200 - 207
反应条件
(CuOTf)2.C6H6; trans-N,N'-dimethylcyclohexane-1,2-diamine; caesium carbonate in N,N-dimethyl-formamide T=120°C; 4 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; DI FABIO, Romano
Patent: WO2012/89606 A1, 2012 ;
Location in patent: Page/Page column 46-47 ;
WO 2012/089606 A1
