1H-1,2,3-三氮唑合成路线 （共 105 条）
反应条件
copper(l) iodide; caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine in N,N-dimethyl-formamide T=120°C; 0.166667 h; Microwave irradiation;
参考文献
MERCK and CO., INC.
Patent: WO2008/8518 A1, 2008 ;
Location in patent: Page/Page column 33-34 ;
WO 2008/008518 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=120°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 13 p. 2390 - 2410
反应条件
3,4,5,6-tetramethyl-t-Bu-X-Phos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=120°C; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8944 - 8947
反应条件
copper(l) iodide; caesium carbonate in N,N-dimethyl-formamide T=20 - 120°C;
参考文献
Qi, Jianjun; Tung, Ching-Hsuan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 320 - 323
反应条件
potassium phosphate; N,N-dimethylethylenediamine in N,N-dimethyl-formamide T=110°C; 8 h;
参考文献
GLENMARK PHARMACEUTICALS, S.A.
Patent: WO2009/90548 A2, 2009 ;
Location in patent: Page/Page column 45 ;
WO 2009/090548 A2
反应条件
3,4,5,6-tetramethyl-t-Bu-X-Phos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=120°C; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8944 - 8947
反应条件
triethylamine in benzene
参考文献
Okumura, Yoshiyuki; Kawamura, Mitsuhiro; Kawai, Makato; Murase, Noriaki; Ikeda, Takafumi
Patent: US2002/42421 A1, 2002 ;
反应条件
triethylamine in benzene T=80°C; 2 h;
参考文献
Ohta, Shunsaku; Kawasaki, Ikuo; Uemura, Takahiro; Yamashita, Masayuki; Yoshioka, Tomomichi; Yamaguchi, Satoshi
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 7 p. 1140 - 1145
反应条件
6 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Larina, Lyudmila I.; Sorokin, Mikhail S.; Albanov, Aleksandr I.; Elokhina, Valentina N.; Protsuk, Nadezhda I.; Lopyrev, Valentin A.
Magnetic Resonance in Chemistry, 1998 , vol. 36, # 2 p. 110 - 115
反应条件
in gaseous matrix T=-261.2°C; Irradiation; Product distributionMechanism;
参考文献
Maier, Guenther; Eckwert, Juergen; Bothur, Axel; Reisenauer, Hans Peter; Schmidt, Christiane
Liebigs Annales, 1996 , # 7 p. 1041 - 1053
