6-乙酰基-1,4-苯并二氧杂环合成路线 （共 16 条）
参考文献
Vazquez; Rosell; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 215 - 217
参考文献
Brunet, Ernesto; Alonso, Maria T.; Juanes, Olga; Sedano, Rosa; Rodriguez-Ubis, Juan C.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4459 - 4462
反应条件
carbon disulfide; aluminium trichloride; acetyl chloride
参考文献
Heertjes et al.
Journal of the Chemical Society, 1957 , p. 3445
Full Text Show Details
Geigy A.G.
Patent: US2383874 , 1942 ;
Full Text Show Details
Denton et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2050,2052
Journal of the American Chemical Society, 1950 , vol. 72, p. 3795
反应条件
1: alkaline aqueous sodium hypochlorite solution 2: acetic acid; sulfuric acid; nitric acid View Scheme
参考文献
Heertjes et al.
Journal of the Chemical Society, 1957 , p. 3445
反应条件
1: With sodium hydroxide; Ca(OCl)2; water; sodium carbonate T=50 - 60°C; 15 h; 2: With hydrogenchloride; water T=0°C; pH=3;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/26829 A2, 2004 ;
Location in patent: Page/Page column 76-77 ;
WO 2004/026829 A2
反应条件
dichloromethane; bromine; calcium carbonate
参考文献
Zhu, Yan-Ping; Cai, Qun; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Meng; Wu, An-Xin
Tetrahedron, 2013 , vol. 69, # 31 p. 6392 - 6398
反应条件
sodium formate; triphenylphosphine; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in toluene T=140°C; Murai reaction; 1.5 h;
参考文献
Martinez, Remi; Simon, Marc-Olivier; Chevalier, Reynald; Pautigny, Cyrielle; Genet, Jean-Pierre; Darses, Sylvain
Journal of the American Chemical Society, 2009 , vol. 131, p. 7887 - 7895
反应条件
[Ru(H2)(CO)(PPh3)3] in toluene T=135°C; Addition; 0.5 h;
参考文献
Sonoda, Motohiro; Kakiuchi, Fumitoshi; Chatani, Naoto; Murai, Shinji
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 12 p. 3117 - 3128
反应条件
1: alkaline aqueous sodium hypochlorite solution 2: thionyl chloride View Scheme
参考文献
Geigy A.G.
Patent: US2383874 , 1942 ;
反应条件
bromine 1.) dioxane, dichloroethane, 2 h: 60-70 deg C, 4 h: reflux; 2.) 2 h: 60-70 deg C, 4 h: reflux; Multistep reaction;
参考文献
Cousse; Mouzin; Bonnaud; Tarayre; Couzinier
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 9 p. 1391 - 1393
