2,3,5,6-四氟吡啶合成路线 （共 61 条）
反应条件
in deuterated toluene T=20°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 155, p. 132 - 142
反应条件
in deuterated toluene T=25°C;
参考文献
Lindup, Richard J.; Marder, Todd B.; Perutz, Robin N.; Whitwood, Adrian C.
Chemical Communications, 2007 , # 35 p. 3664 - 3666
反应条件
potassium phosphate in 1-methyl-pyrrolidin-2-one T=50 - 165°C; 12.5 - 18.5 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2006/15194 A2, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2.1: 65 percent / aq. CuSO4 / Heating 3.1: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating 4.1: 79 percent / aq. CuSO4 / Heating 5.1: BuLi / tetrahydrofuran; hexane 5.2: 73 percent / hexachloroethane / tetrahydrofuran; hexane View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
in deuterated toluene T=25°C;
参考文献
Chemical Communications, , # 35 p. 3664 - 3666
反应条件
triethylsilane; [Rh(μ-H)(1,3-bis(diisopropylphosphanyl)propane)]2 in benzene-d6 T=50°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 155, p. 132 - 142
反应条件
in deuterated toluene T=20°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Zamostna, Lada; Ahrens, Mike; Braun, Thomas
Journal of Fluorine Chemistry, 2013 , vol. 155, p. 132 - 142
反应条件
1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2: 65 percent / aq. CuSO4 / Heating View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
triethylsilane; [Rh(μ-H)(1,3-bis(diisopropylphosphanyl)propane)]2 in benzene-d6 T=50°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 155, p. 132 - 142
反应条件
1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2: 65 percent / aq. CuSO4 / Heating 3: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating 4: 79 percent / aq. CuSO4 / Heating View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
