3-甲硫基-1,2,4-三嗪合成路线 （共 16 条）
反应条件
sodium hydrogencarbonate in water T=0 - 20°C; 18 h;
参考文献
PIERRE FABRE MEDICAMENT; Leroy, Isabelle; Dupont-Passelaigue, Elisabeth; Mialhe, Samuel; Junquero, Didier; Valeille, Karine
Patent: US2013/40928 A1, 2013 ;
Location in patent: Paragraph 0226; 0227; 0228 ;
反应条件
sodium hydrogencarbonate in water 0.166667 h; Cooling with ice;
参考文献
Ban, Kung; Duffy, Sandra; Khakham, Yelena; Avery, Vicky M.; Hughes, Andrew; Montagnat, Oliver; Katneni, Kasiram; Ryan, Eileen; Baell, Jonathan B.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 6024 - 6029
反应条件
in ethanol 25 h; Heating;
参考文献
Alekseev, S. G.; Charushin, V. N.; Chupakhin, O. N.; Shorshnev, S. V.; Chernyshev, A. I.; Klyuev, N. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 11 p. 1242 - 1249
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 11 p. 1535 - 1543
反应条件
in xylene 72 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Golka; Keyte; Paddon-Row
Tetrahedron, 1992 , vol. 48, # 36 p. 7663 - 7678
反应条件
in methanol T=20°C; 24 h;
参考文献
Ban, Kung; Duffy, Sandra; Khakham, Yelena; Avery, Vicky M.; Hughes, Andrew; Montagnat, Oliver; Katneni, Kasiram; Ryan, Eileen; Baell, Jonathan B.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 6024 - 6029
反应条件
copper(I) bromide dimethylsulfide complex; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether Stille cross-coupling; 48 h; Heating;
参考文献
Alphonse, France-Aimee; Suzenet, Franck; Keromnes, Anne; Lebret, Bruno; Guillaumet, Gerald
Synthesis, 2004 , # 17 p. 2893 - 2899
反应条件
potassium permanganate; ammonia
T=-33°C; 0.25 h;
参考文献
Rykowski, A.; Plas, H. C. van der
Synthesis, 1985 , # 9 p. 884 - 886
反应条件
in water
24 h; Ambient temperature;
参考文献
Jacobsen, Noel W.; Jonge, Ian de
Australian Journal of Chemistry, 1987 , vol. 40, # 12 p. 1979 - 1988
反应条件
in tetrahydrofuran
T=20°C; 20 h;
参考文献
Alphonse, France-Aimee; Suzenet, Franck; Keromnes, Anne; Lebret, Bruno; Guillaumet, Gerald
Synthesis, 2004 , # 17 p. 2893 - 2899
反应条件
potassium hydroxide in dimethyl sulfoxide
参考文献
Rykowski, Andrzej; Makosza, Mieczyslaw
Liebigs Annalen der Chemie, 1988 , p. 627 - 632
