4-氯吡咯并[2,3-D]嘧啶合成路线 （共 8 条）
反应条件
trichlorophosphate in water
参考文献
Pharmacia and Upjohn S.p.A.
Patent: US5965563 A1, 1999 ;
反应条件
1: 55 percent / 2 h / 170 °C 2: POCl3 / 1 h / Heating View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
1: aqueous KMnO4 / Erwaermen des Reaktionsprodukts mit wss. HCl 2: 170 °C 3: POCl3 View Scheme
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
trichlorophosphate 1 h; Heating;
参考文献
Sanmartin, Carmen; Echeverria, Mikel; Mendivil, Beatriz; Cordeu, Lucia; Cubedo, Elena; Garcia-Foncillas, Jesus; Font, Maria; Palop, Juan Antonio
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 2031 - 2044
参考文献
Robins; Hitchings
Journal of the American Chemical Society, 1955 , vol. 77, p. 2256,2259
反应条件
triethylamine in benzene
1.75 h; Heating;
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
1: 74 percent / NEt3 / benzene / 1.75 h / Heating
2: 98 percent / polyphosphoric acid / 5 h / 120 °C
View Scheme
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
反应条件
1: 74 percent / NEt3 / benzene / 1.75 h / Heating
2: 98 percent / polyphosphoric acid / 5 h / 120 °C
3: 71 percent / aq. NaHCO3 / 0.5 h / Heating
View Scheme
参考文献
Petric, Andrej; Tisler, M.; Stanovnik, Branko
Monatshefte fuer Chemie, 1983 , vol. 114, p. 615 - 624
