(S)-(-)-1-Cbz-2-哌啶甲酸合成路线 （共 14 条）
反应条件
potassium hydroxide in methanol; water
参考文献
Golec, Julian M.C.
Patent: US2002/61853 A1, 2002 ;
反应条件
chromium(VI) oxide; sulfuric acid in acetone T=0°C; 0.25 h;
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
potassium permanganate; magnesium sulfate in acetone 0.5 h; Ambient temperature;
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
参考文献
Dr. Lo Zambeletti S.p.A.
Patent: US4826819 A1, 1989 ;
反应条件
1: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 2: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT 3: 76 percent / KMnO4, MgSO4 / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
1: 90 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature 2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT 4: 76 percent / KMnO4, MgSO4 / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
1: 90 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature 2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT 4: 76 percent / KMnO4, MgSO4 / acetone / 0.5 h / Ambient temperature View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
反应条件
sodium hydroxide 6 h; Ambient temperature;
参考文献
Gurjar; Ghosh, Lakshmi; Syamala; Jayasree
Tetrahedron Letters, 1994 , vol. 35, # 47 p. 8871 - 8872
反应条件
resolution with D-tyrosinehydrazide;
参考文献
Coppola, Gary M.; Damon, Robert E.; Eskesen, J. Bruce; France, Dennis S.; Paterniti Jr., James R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 809 - 812
反应条件
hydrogen; palladium on activated charcoal in methanol P=2327.2 Torr; 6 h; Ambient temperature;
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
