4-甲基噻吩-2-甲基羧酸盐合成路线 （共 14 条）
反应条件
sulfuric acid Heating / reflux;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2004/113281 A1, 2004 ;
Location in patent: Page 74 ;
反应条件
acetic acid in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5840917 A1, 1998 ;
反应条件
acetic acid; zinc 4 h; Heating;
参考文献
Kozmik, Vaclav; Palecek, Jaroslav
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 7 p. 1483 - 1486
反应条件
1: 3-methyl thiophene With n-butyllithium in tetrahydrofuran T=0°C; 2: methyl chloroformate in tetrahydrofuran T=0°C; 16 h;
参考文献
Suaifan, Ghadeer A.R.Y.; Goodyer, Claire L.M.; Threadgill, Michael D.
Molecules, 2010 , vol. 15, # 5 p. 3121 - 3134
反应条件
1: 3-methyl thiophene With n-butyllithium in diethyl ether; hexane T=0°C; 2: N,N-dimethyl-formamide in diethyl ether; hexane T=0°C; 3: methanol Further stages;
参考文献
Suaifan, Ghadeer A.R.Y.; Goodyer, Claire L.M.; Threadgill, Michael D.
Molecules, 2010 , vol. 15, # 5 p. 3121 - 3134
反应条件
iron (III) acetylacetonate T=140°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
1: 1.) ZnCl2, HCl, 2.) Zn, CH3COOH / 1.) 1,2-dichloroethane, RT, 5 h, 2.) RT, 24 h 2: 82 percent / Zn, CH3COOH / 4 h / Heating View Scheme
参考文献
Kozmik, Vaclav; Palecek, Jaroslav
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 7 p. 1483 - 1486
参考文献
Nakaya et al.
Nippon Kagaku Zasshi, 1957 , vol. 78, p. 935,938
Chem.Abstr., 1959 , p. 21276
参考文献
Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842
反应条件
water T=25°C; Kinetics;
参考文献
Choi, Hojune; Koo, In Sun
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 2 p. 499 - 504
