S-2-溴-4-甲基戊酸合成路线 （共 17 条）
反应条件
nitrosyl bromide 2-bromo-4-methyl-valeric acid , l-form;
参考文献
Pharmacia and Upjohn S.p.A.
Patent: US6194451 B1, 2001 ;
US 6194451 B1
反应条件
potassium bromide; sodium nitrite in sulfuric acid
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US5594006 A1, 1997 ;
US 5594006 A
反应条件
hydrogen bromide; sodium nitrite
参考文献
Nicolaides, E. D.; Tinney, F. J.; Kaltenbronn, J. S.; Repine, J. T.; DeJohn, D. A.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 959 - 971
反应条件
1: 2 N aq. NaOH / ethanol 2: neat (no solvent) / 100 °C 3: 24.3 g / Br2, PCl3 / 1.) 80 - 85 deg C, 3 h, 2.) 100 deg C, 1 h View Scheme
参考文献
Kortylewicz; Galardy
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 263 - 273
反应条件
1: neat (no solvent) / 100 °C 2: 24.3 g / Br2, PCl3 / 1.) 80 - 85 deg C, 3 h, 2.) 100 deg C, 1 h View Scheme
参考文献
Kortylewicz; Galardy
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 263 - 273
反应条件
bromine; phosphorus trichoride T=80 - 85°C;
参考文献
Kortylewicz; Galardy
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 263 - 273
反应条件
hydrogen bromide dampft zur Trockne ein, loest den Rueckstand im Bromwasserstoffsaeure, gibt Brom hinzu und leitet in die Loesung bei 0grad Stickoxyd ein; 2-bromo-4-methyl-valeric acid , d-form;
参考文献
Fischer,E.
Chemische Berichte, 1906 , vol. 39, p. 2930
反应条件
2-bromo-4-methyl-valeric acid , d-form;
参考文献
Fischer,E.; Carl
Chemische Berichte, 1906 , vol. 39, p. 3999
反应条件
2-bromo-4-methyl-valeric acid , l-form;
参考文献
Chemische Berichte, , vol. 39, p. 3999
反应条件
1: 79 percent / sulfuric acid / 1 h / Heating 2: 66 percent / zinc; dibromoethane / various solvent(s) / 1.5 h / 20 °C 3: Pd/C; ammonium formate / tetrahydrofuran; methanol / 20 °C 4: LiOH / H2O View Scheme
参考文献
Moumne, Roba; Lavielle, Solange; Karoyan, Philippe
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3332 - 3334
