2'-氨基-4',5'-亚甲二氧基苯乙酮合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Bertha, P.; Fetter, J.; Lempert, K.; Moeller, J.; Radics, L.
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4737 - 4744
反应条件
1: With sulfuric acid T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique; 2: With sodium hydrogencarbonate Inert atmosphereSchlenk technique;
参考文献
Bhanuchandra; Ramu Yadav; Rit, Raja K.; Rao Kuram, Malleswara; Sahoo, Akhila K.
Chemical Communications, 2013 , vol. 49, # 45 p. 5225 - 5227
反应条件
in various solvent(s) 25 h; Irradiation;
参考文献
Barta-Szalai, G.; Fetter, J.; Lempert, K.; Moller, J.
Acta Chimica Academiae Scientiarum Hungaricae, 1980 , vol. 104, p. 253 - 266
反应条件
25 h; Ambient temperature;
参考文献
Barta-Szalai, G.; Fetter, J.; Lempert, K.; Moller, J.
Acta Chimica Academiae Scientiarum Hungaricae, 1980 , vol. 104, p. 253 - 266
反应条件
hydrogenchloride; sodium methylate in ethylene glycol dimethyl ether; water
参考文献
Kirin Beer Kabushiki Kaisha
Patent: US6187926 B1, 2001 ;
反应条件
potassium tert-butylate; triethylamine in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; tert-butyl alcohol
参考文献
The University of North Carolina at Chapel Hill
Patent: US6569870 B1, 2003 ;
反应条件
1: Et3N / tetrahydrofuran / 0 - 20 °C 2: potassium tert-butoxide / 2-methyl-propan-2-ol / 24 h / 70 °C View Scheme
参考文献
Li; Wang; Kuo; Wu; Lednicer; Lin; Hamel; Lee -
Journal of Medicinal Chemistry, 1994 , vol. 37, # 8 p. 1126 - 1135
反应条件
sodium carbonate in dichloromethane
0.5 h; Ambient temperature;
参考文献
Bertha, F.; Fetter, J.; Lempert, K.; Moeller, J.
Acta Chimica Academiae Scientiarum Hungaricae, 1982 , vol. 111, # 2 p. 213 - 224
反应条件
1.1: 89 percent / NaH / Heating
2.1: 91 percent / POCl3 / 2 h / Heating
3.1: phenol / 2.5 h / Heating
3.2: 65 percent / phenol / 20 h / Heating
4.1: 1.44 g / Et3N / CH2Cl2 / 16 h / Heating
5.1: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag2CO3 / dimethylformamide / 0.5 h / Heating
6.1: 95 percent / formic acid; AcOH / Pd black / 1.5 h / 20 °C
View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
1: 89 percent / NaH / Heating
2: 91 percent / POCl3 / 2 h / Heating
View Scheme
参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
