1-苄基-1,3-二氢-2H-苯并咪唑-2-酮合成路线 （共 22 条）
反应条件
1: 80 percent / 0.08 h / 200 °C
2: 95 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
3: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: 94 percent / K2CO3 / acetonitrile / 0.5 h / Heating
2: 91 percent / K2CO2 / acetonitrile / Heating
3: 86 percent / 5 N NaOH / ethanol
View Scheme
参考文献
Meanwell; Sit; Gao; Wong; St. Laurent; Balasubramanian
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1565 - 1582
反应条件
1: 91 percent / K2CO2 / acetonitrile / Heating
2: 86 percent / 5 N NaOH / ethanol
View Scheme
参考文献
Meanwell; Sit; Gao; Wong; St. Laurent; Balasubramanian
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1565 - 1582
反应条件
1: 91 percent / K2CO2 / acetonitrile / Heating
2: 86 percent / 5 N NaOH / ethanol
View Scheme
参考文献
Meanwell; Sit; Gao; Wong; St. Laurent; Balasubramanian
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1565 - 1582
反应条件
1: 97 percent / DEAD, PPh3 / tetrahydrofuran / Ambient temperature
2: 86 percent / 5 N NaOH / ethanol
View Scheme
参考文献
Meanwell; Sit; Gao; Wong; St. Laurent; Balasubramanian
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1565 - 1582
反应条件
potassium hydroxide
Heating;
参考文献
Divaeva; Kuzmenko; Morkovnik; Komissarov
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 4 p. 463 - 468
反应条件
calcium chloride
T=210°C; 1.5 h; Yield given;
参考文献
Gomez-Parra, Vicente; Sanchez, Felix; Torres, Tomas
Monatshefte fuer Chemie, 1985 , vol. 116, p. 639 - 644
反应条件
1: 80 percent / KOH / aq. ethanol / 60 - 70 °C
2: 60 percent / aq. KOH / Heating
View Scheme
参考文献
Divaeva; Kuzmenko; Morkovnik; Komissarov
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 4 p. 463 - 468
反应条件
1: 80 percent / KOH / aq. ethanol / 60 - 70 °C
2: 60 percent / aq. KOH / Heating
View Scheme
参考文献
Divaeva; Kuzmenko; Morkovnik; Komissarov
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 4 p. 463 - 468
反应条件
sodium hydride
1.) DMF, 2.) DMF, RT; Multistep reaction;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
