4-羟基-2,6-二甲基苯甲醇合成路线 （共 7 条）
反应条件
1: 3,5-dimethyl-phenol With sodium hydroxide in water 1.5 h; Industry scale; 2: formaldehyd in water T=4 - 20°C; Industry scale; 3: With hydrogenchloride in dichloromethane; water; ethyl acetate pH=5; 6.5 h; Industry scale;
参考文献
METABASIS THERAPEUTICS, INC.; BOYER, Serge H.; ERION, Mark D.; ITO, Bruce; JACINTHO, Jason
Patent: WO2011/38207 A1, 2011 ;
Location in patent: Page/Page column 96 ;
反应条件
sodium tetrahydroborate in ethanol 1.) 0 deg C, 4 h, 2.) 25 deg C, overnight;
参考文献
Marx, John N.; Bih, Qoang-Rung
Journal of Organic Chemistry, 1987 , vol. 52, # 3 p. 336 - 338
反应条件
1: 1.) HCl, 2.) AlCl3, HCl / 1.) benzene, 25 deg C, 1 h, 2.) benzene, 40-45 deg C, 4 h 2: HCl / H2O / 1 h 3: 92 percent / NaBH4 / aq. ethanol / 1.) 0 deg C, 4 h, 2.) 25 deg C, overnight View Scheme
参考文献
Marx, John N.; Bih, Qoang-Rung
Journal of Organic Chemistry, 1987 , vol. 52, # 3 p. 336 - 338
反应条件
triethylamine in tetrahydrofuran 48 h;
参考文献
Marx, John N.; Bih, Qoang-Rung
Journal of Organic Chemistry, 1987 , vol. 52, # 3 p. 336 - 338
反应条件
1,4-dioxane; copper oxide-chromium oxide T=200°C; Hydrogenation;
参考文献
Fitzgerald
Journal of Applied Chemistry, 1955 , vol. 5, p. 289,293
反应条件
1: aqueous NaOH 2: acetone; aqueous potassium permanganate View Scheme
参考文献
Burawoy; Chamberlain
Journal of the Chemical Society, 1949 , p. 624
反应条件
1: copper oxide-chromium oxide; dioxane / 200 °C / Hydrogenation
2: methanol
3: copper oxide-chromium oxide; dioxane / 180 °C / 154457 Torr / Hydrogenation
View Scheme
参考文献
Fitzgerald
Journal of Applied Chemistry, 1955 , vol. 5, p. 289,293
