2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮合成路线 （共 3 条）
反应条件
1: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine in dichloromethane T=20°C; Substitution; 0.166667 h; 2: morpholine in dichloromethane T=20°C; Acylation; Further stages.;
参考文献
Kalgutkar, Amit S.; Marnett, Alan B.; Crews, Brenda C.; Remmel, Rory P.; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2860 - 2870
反应条件
1: DCC / tetrahydrofuran 2: 1.) KHMDS, HMPA / 1.) THF View Scheme
参考文献
Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; potassium hexamethylsilazane 1.) THF; Multistep reaction;
参考文献
Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268
