1H-苯并三唑-1-甲醇合成路线 （共 47 条）
反应条件
1: 60 percent / acetic acid / 0.25 h / Heating 2: 66 percent / conc. HCl / methanol; H2O / 72 h / Heating View Scheme
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Lam, Jamshed N.
Synthesis, 1990 , p. 341 - 346
反应条件
1: anhydrous propionitrile With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran T=-78°C; 2 h;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Organic Letters, 2007 , vol. 9, # 6 p. 1165 - 1167
反应条件
1: in ethanol T=-5°C; Inert atmosphereReflux; 2: With sodium tetrahydroborate in tetrahydrofuran 1 h; Reflux;
参考文献
Uno, Masaharu; Koma, Yosuke; Ban, Hyun Seung; Nakamura, Hiroyuki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5169 - 5173
反应条件
1: (phenylsulfonyl)methane With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran T=-78°C; 2 h;
参考文献
Organic Letters, , vol. 9, # 6 p. 1165 - 1167
反应条件
sodium tetrahydroborate Multistep reaction;
参考文献
Linstroem, Stefan; Eriksson, Mikael; Grivas, Spiros
Acta Chemica Scandinavica, 1993 , vol. 47, # 8 p. 805 - 812
反应条件
1: 3-methoxybenzyl-triphenylphosphonium chloride With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran T=-78°C; Wittig olefination; 2 h;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Organic Letters, 2007 , vol. 9, # 6 p. 1165 - 1167
反应条件
thionyl chloride T=0°C; 1 h; Heating / reflux;
参考文献
Le Borgne, Marc; Na, Young Min; Pagniez, Fabrice; Le Baut, Guillaume; Le Pape, Patrice; Abdala, Hiam
Patent: US2004/67998 A1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
1: SOCl2 / toluene / 2 h / Heating 2: 40 percent / methanol / 1 h / Heating View Scheme
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Rachwal, Bogumila
Journal of Organic Chemistry, 1989 , vol. 54, # 26 p. 6022 - 6029
反应条件
1: 60 percent / acetic acid / 0.25 h / Heating 2: 72 percent / methanol; H2O / 72 h / Heating View Scheme
参考文献
Katritzky, Alan R.; Lan, Xiangfu; Lam, Jamshed N.
Synthesis, 1990 , p. 341 - 346
反应条件
1: 3,4-dihydronaphthalene-1(2H)-one With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: 1-Hydroxymethyl-1H-benzotriazole in tetrahydrofuran T=-78°C; 2 h;
参考文献
Deguest, Geoffrey; Bischoff, Laurent; Fruit, Corinne; Marsais, Francis
Organic Letters, 2007 , vol. 9, # 6 p. 1165 - 1167
