(2S)-2-(乙酰氨基)-4-甲基-戊酰胺合成路线 （共 8 条）
反应条件
ammonia in toluene T=80°C; 0.5 h;
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
1: 99 percent / 4N NaOH / 1 h / 0 °C 2: 1.) isobutylchloroformate, N-ethylmorpholine, 2.) ammonia / 1.) -15 deg C, 5 min, 2.) -15 deg C, 30 min 3: 1.) 5percent Pd/C / 1.) 80percent glacial acetic acid, overnight, 2.) pyridine View Scheme
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
1: 1.) isobutylchloroformate, N-ethylmorpholine, 2.) ammonia / 1.) -15 deg C, 5 min, 2.) -15 deg C, 30 min 2: 1.) 5percent Pd/C / 1.) 80percent glacial acetic acid, overnight, 2.) pyridine View Scheme
参考文献
Kent, Hilary E.; Lilley, Terence H.; Milburn, Peter J.; Bloemendal, Michael; Somsen, Gus
Journal of Solution Chemistry, 1985 , vol. 14, # 2 p. 101 - 116
反应条件
palladium on activated charcoal 1.) 80percent glacial acetic acid, overnight, 2.) pyridine; Yield given. Multistep reaction;
参考文献
Kent, Hilary E.; Lilley, Terence H.; Milburn, Peter J.; Bloemendal, Michael; Somsen, Gus
Journal of Solution Chemistry, 1985 , vol. 14, # 2 p. 101 - 116
参考文献
Blackburn, G. Michael; Lilley, Terence H.; Walmsley, Elizabeth
Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, 1980 , vol. 76, p. 915 - 922
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; Kinetics;
参考文献
Permyakov; Medvedkin
Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 1 p. 9 - 13
反应条件
zinc(II) iodide in chloroform
4 h; Heating;
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
反应条件
zinc(II) chloride in chloroform
3.5 h; Heatingother reagent, other reaction time, other benzoyl halide (BzCl); Product distribution;
参考文献
Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E.
Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713
