2-(甲硫基)-5-硝基-1,3-苯并恶唑合成路线 （共 5 条）
反应条件
1: 4-nitro-1,3-benzoaxazolidine-2-thione With sodium hydride in tetrahydrofuran T=5°C; 0.25 h; 2: methyl iodide in tetrahydrofuran T=20°C; 5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 47-48 ;
WO 2006/066173 A2
反应条件
in N,N-dimethyl-formamide T=25°C; 4 h;
参考文献
Ongarora, Dennis S.B.; Gut, Jiri; Rosenthal, Philip J.; Masimirembwa, Collen M.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5046 - 5050
参考文献
Makosza, Mieczyslaw; Stalewski, Jacek
Tetrahedron, 1995 , vol. 51, # 26 p. 7277 - 7286
反应条件
1: acetic acid / ethanol / 4.5 h / pH 5 / Reflux 2: N,N-dimethyl-formamide / 4 h / 25 °C View Scheme
参考文献
Ongarora, Dennis S.B.; Gut, Jiri; Rosenthal, Philip J.; Masimirembwa, Collen M.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5046 - 5050
反应条件
in diethyl ether T=10°C; 0.0333333 h;
参考文献
Zinner,H. et al.
Chemische Berichte, 1960 , vol. 93, p. 2035 - 2040
