N-(叔丁基)-对甲苯磺酰胺合成路线 （共 28 条）
反应条件
1: 1) ClNO; 2) TsCl / 1) pyridine, 20 deg C, 2 h, 80 deg C, 1 h; 2) -10 deg C -> 20 deg C, 2 h
2: 82.6 percent / 20 - 100 °C / 10 h at 20 deg C, 1 h at 100 deg C
View Scheme
参考文献
Kostyanovsky, R. G.; Shustov, G. V.; Zaichenko, N. L.
Tetrahedron, 1982 , vol. 38, # 7 p. 949 - 960
反应条件
copper(I) bromide dimethylsulfide complex
1) THF, HMPA, ether, -16 deg C, 15 min, 2) THF, HMPA, -16 deg C, 80 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Baldwin, Jack E.; Spivey, Alan C.; Schofield, Christopher J.; Sweeney, Joseph B.
Tetrahedron, 1993 , vol. 49, # 28 p. 6309 - 6330
参考文献
Monjoint, Pierre; Ruasse, Marie-Francoise
Tetrahedron Letters, 1984 , vol. 25, # 30 p. 3183 - 3186
反应条件
hydrogenchloride; anhydrous tetramethylammonium chloride in ethanol
T=25°C; μ=0.16 M; Rate constant;
参考文献
Monjoint, P.; Ruasse, M. F.
Bulletin de la Societe Chimique de France, 1988 , # 2 p. 356 - 360
反应条件
in tetrahydrofuran; hexane; toluene
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4479901 A1, 1984 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
2 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; hexane
3 h; Further stages.;
参考文献
Hashimoto, Hiromasa; Imamura, Katsuaki; Haruta, Jun-Ichi; Wakitani, Korekiyo
Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1511 - 1517
反应条件
1: butyl-lithium / hexane
2: hexane / 2 h / Heating
View Scheme
参考文献
Iley, Jim; Bassindale, Alan R.; Patel, Pravin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 1 p. 77 - 80
反应条件
potassium permanganate
参考文献
Briscoe et al.
Journal of the Chemical Society, 1956 , p. 1755,1762
