7-氯-5-(2-氯苯基)-1,3-二氢-2-氧代-2H-1,4-苯并二氮杂卓-3-基乙酸酯合成路线 （共 4 条）
反应条件
dipotassium peroxodisulfate; iodine in acetic acid T=65 - 70°C; 5.5 h; Large scale; Reagent/catalystTemperatureTime;
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
1: toluene / 3.5 h / 10 - 20 °C 2: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 3: dipotassium peroxodisulfate; iodine / acetic acid / 5.5 h / 65 - 70 °C / |Large scale View Scheme
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
1: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; ammonium acetate / ethanol / 6 h / |Reflux 2: dipotassium peroxodisulfate; iodine / acetic acid / 5.5 h / 65 - 70 °C / |Large scale View Scheme
参考文献
Cepanec, Ivica; Litvic, Mladen; Pogorelic, Ivan
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1192 - 1198
反应条件
sodium hydroxide in ethanol T=10°C; 0.116667 h;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 32, # 2 p. 102 - 105
