4-甲氧基-3-戊烯-2-酮合成路线 （共 5 条）
反应条件
acetic acid; zinc 20 h;
参考文献
Tetrahedron, , vol. 49, # 20 p. 4409 - 4418
参考文献
Gelin,S. et al.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1967 , vol. 265, p. 1483 - 1485
反应条件
1.1: sodium t-butanolate / tetrahydrofuran / 2 h / 30 - 45 °C
1.2: 6 h / 55 °C
2.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 1.08 h / -78 - 0 °C / Inert atmosphere
View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; LIU, Xiaogao; LIN, Edward, Yin-Shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin, M.; KUMARAVEL, Gnanasambandam; TAVERAS, Arthur, G.
Patent: WO2011/17561 A1, 2011 ;
WO 2011/017561 A1
反应条件
in toluene
T=200°C; 16 h; Inert atmosphere;
参考文献
Lee, Jennifer J.; Kraus, George A.
Tetrahedron Letters, 2013 , vol. 54, # 19 p. 2366 - 2368
