反应条件
1: Na2CO3 / H2O / 1 h / Heating
2: NaOH / ethanol; H2O / 16 h / 25 °C
3: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr
4: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h
5: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C
6: Lawesson's reagent / toluene
7: NaOH / tetrahydrofuran; ethanol
8: NH3 / methanol
View Scheme
参考文献
Varney, Michael D.; Marzoni, Gifford P.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 663 - 676
