1.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C 1.2: tetrahydrofuran; toluene / 3 h / -78 - 0 °C 2.1: K2CO3; methanol / 2 h / 20 °C 3.1: 691 mg / aq. HCl / tetrahydrofuran / 2 h / Heating View Scheme

1: K2CO3; methanol / 2 h / 20 °C 2: 691 mg / aq. HCl / tetrahydrofuran / 2 h / Heating View Scheme

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / N,N-dimethyl-formamide / 80 °C 2.1: n-butyllithium / tetrahydrofuran 3.1: potassium carbonate / methanol 3.2: Reflux View Scheme

(i) NaNH2, liq. NH3, THF, (ii) H2O; Multistep reaction;